Mexiletine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

抗心律失常药，药理学与利多卡因相似。它可能具有一些抗惊厥特性。

Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.

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Animal Model:Male Sprague-Dawley rats with Oxaliplatin (HY-17371)-induced neuropathic pain Dosage:Oxaliplatin (4 mg /kg) and Mexiletine(10, 30, 100 mg/kg) Administration:Oxaliplatin, Intraperitoneal injection (i.p.)in days 1, 2, 8, 9, 15, 16, 22, and 23; Mexiletine, Oral gavage (p.o.), acute administration Result:100 mg/kg completely reversed the reduction of 50% paw withdrawal threshold by Oxaliplatin at 60 min after administration in the von Frey test, completely reversed the increase of number of withdrawal responses at 60 and 120 min after administration in the acetone test. 30 mg/kg partly reversed the symptom and 10 mg/kg did not reverse any symptom. The effect disappeared by 180 min after administration.

Ko 1173

Endocrinology/Hormones

AhR

AhR| Voltage-gated sodium channel

Cardiovascular Disease

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5370-01-4

215.72

C11H18ClNO

>98% (HPLC)

Ethanol: 43 mg/mL (199.33 mM); Water: 43 mg/mL (199.33 mM); DMSO: 43 mg/mL (199.33 mM)

[Cl-].CC([NH3+])COC1=C(C)C=CC=C1C

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(-20℃)

With Ice Pack

≥ 2 years